Discovery of the tRNA modified nucleotides and modification enzyme network

C. Tomikawa, T. Yokogawa, T. Kanai, and H. Hori,
“N7-Methylguanine at position 46 (m7G46) in tRNA from Thermus thermophilus is required for cell viability through a tRNA modification network.”
Nucleic Acids Res. 38, 942-957 (2010)

K. Ishida, T. Kunibayashi, C. Tomikawa, A. Ochi, T. Kanai, A. Hirata, C. Iwashita, and H. Hori,
”Pseudouridine at position 55 (Y55) in tRNA controls the contents of other modified nucleotides  for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus.”
Nucleic Acids Res. 39, 2304-2318 (2011)

Dr. Chie Tomikawa won the Whole Cell Award in the 9th International Annual Meeting of Model Organism Structural-Biological Whole Cell Project by these studies.